- Sandwich Shop Restaurants, Londonderry
- Scales Retail, Londonderry
- School Bus Transportation Service, Londonderry
- Schools Montessori Instruction, Londonderry
- Science & Research, Londonderry
- Scientific Equipment & Services, Londonderry
- Scientific Services, Londonderry
- Scrap & Waste Machinery, Londonderry
- Scrap & Waste Materials, Londonderry
- Screen Printing, Londonderry
- Sealcoating, Londonderry - Asphalt Sealcoating & Paving
- Seawall & Shoring Contractors, Londonderry
- Security & Surveillance System & Equipment, Londonderry
- Security Alarm Systems - Home & Business, Londonderry
- Security Brokers & Dealers, Londonderry
- Security Control Systems & Monitoring, Londonderry - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Investigative Services, Londonderry
- Security Services, Londonderry
- Septic Tank Pumping & Cleaning, Londonderry - Septic Systems
- Service Establishment Supplies & Equipment, Londonderry
- Sewer & Drain Cleaning & Repair, Londonderry - Drain Cleaner & Installation Services
- Sheet Metal, Londonderry
- Sheet Metal Fabricators & Ductwork Contractors, Londonderry
- Sheet Metal Work - Aluminum, Tin, Stainless Steel, etc, Londonderry - Sheet Metal Products
- Shipping Service, Londonderry
- Shopping & Shopping Services, Londonderry
- Shoring Contractors, Londonderry
- Siding Contractors, Londonderry - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Signs, Londonderry
- Small Appliances, Londonderry
- Snack Foods, Londonderry
- Snacks & Desserts, Londonderry
- Snow Removal Services, Londonderry - Snow Plow Service
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- Social Services & Welfare, Londonderry
- Social Workers & Services, Londonderry
- Societies & Foundation Associations, Londonderry
- Soil Consultants, Londonderry
- Southern Style Restaurants, Londonderry
- Special Coatings, Londonderry - Protective Coatings
- Special Dies Tools Jigs & Fixtures Manufacturers, Londonderry
- Special Education & Care, Londonderry
- Special Interest Schools Or Instruction, Londonderry
- Specialty Stores, Londonderry
- Speech & Hearing Specialists, Londonderry
- Speech & Language Therapy, Londonderry
- Speech Pathologists, Londonderry - Speech & Language Therapy
- Sporting & Recreational Camps, Londonderry
- Sporting Goods Stores, Londonderry
- Sports & Recreational Services, Londonderry
- Springs Automotive, Londonderry
- Sprinkler Alarm Systems, Londonderry - Fire Sprinkler Systems
- Staffing & Support Services, Londonderry
- State Government, Londonderry
- Stationery & Office Supplies, Londonderry
- Steam Cleaner - Commercial & Industrial, Londonderry - Steam Cleaning - Upholstery, Floor, Carpet, etc
- Stocks & Bond Brokers, Londonderry
- Storage Containers, Londonderry
- Store Fixtures & Display Equipment, Londonderry
- Submarine Sandwich Restaurants, Londonderry
- Sunrooms & Solarium Construction Contractors, Londonderry - Build & Repair
- Sunrooms, Greenhouses, Solariums & Atrium Builders, Londonderry - Build & Repair
- Surplus & Salvage Merchandise, Londonderry
- Surveyor Services, Londonderry - Surveying Service
- Sweepers & Scrubbers Industrial, Londonderry - Sweeping Service
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Londonderry
- Swimming Pools Supplies, Equipment & Accessories, Londonderry
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